Computer simulation of aggregation in Dictyostelium discoideum.
J Cell Sci, 1978/10;33:1-16.
PMID: 214452
Impact factor: 5.235
Abstract
The aggregation phase of development of the cellular slime mould Dictyostelium discoideum is simulated on a computer. The simulation is performed in 2 dimensions, and produces animated graphical output similar to time-lapse films. It is based on observations of cell behaviour as expressed by a set of rules for each cell, involving cell movement and release of and response to chemical signals. Following these rules, the simulation has reproduced many observed aggregation patterns: propagating waves of cell movement; formation of branching streams; entrainment of slower centres; and spiral centre formation. The simulation has proved to be an important adjunct to experimental work.
MeSH terms
Cell Aggregation; Chemotaxis; Cyclic AMP; Dictyostelium; Interphase; Models, Biological; Morphogenesis; Phosphoric Diester Hydrolases
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