The effect of age and thyroid hormones upon the ability of the chick heart to deaminate monoamines.
J Pharm Pharmacol, 1977/10;29(10):593-7.
PMID: 21237
Impact factor: 4.81
Abstract
The effect of age and thyroid hormones upon the ability of chick heart homogenates to metabolize monoamines has been investigated. 5-Hydroxytryptamine is entirely metabolized by a monoamine oxidase (MAO) with the characteristics of MAO-A, whereas some of the tyramine and all of the benzylamine are oxidatively deaminated by a clorgyline-resistant, but semicarbazide-sensitive enzyme, with a similar subcellular distribution to that of MAO. The remainder of the tyramine deamination is brought about by MAO-A and MAO-B. The specific activities of both clorgyline-sensitive and resistant enzymes are increased by the same proportion by increase in age or by treatment with (--)-thyroxine, and decreased by 2-thiouracil. The significance of these results is discussed.
MeSH terms
Animals; Biogenic Amines; Chickens; Clorgyline; Deamination; Heart; In Vitro Techniques; Monoamine Oxidase; Myocardium; Subcellular Fractions; Thyroid Hormones
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