Action of six commonly used benzodiazepines on isolated guinea-pig ileum preparation.
Arch Int Pharmacodyn Ther, 1975/11;218(1):77-83.
Huck S, Stacher G, Gogolák G, Stumpf C
PMID: 2123
Abstract
The spasmolytic activity of six commonly used benzodiazepines was investigated on isolated guinea-pig ileum preparation. All six substances proved to be non-competitive antagonists of carbachol and barium chloride, the pD'2 values ranging between 3.23 and 4.37 in the presence of either agonist. The significance of these findings is discussed.
MeSH terms
Animals; Anti-Anxiety Agents; Barium; Benzodiazepines; Carbachol; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Papaverine
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