Streptomyces turgidiscabies Car8 contains a modular pathogenicity island that shares virulence genes with other actinobacterial plant pathogens.
Plasmid, 2011/3;65(2):118-24.
Huguet-Tapia JC[1], Badger JH, Loria R, Pettis GS
Affiliations
PMID: 21087627DOI: 10.1016/j.plasmid.2010.11.002
Impact factor: 3.085
Abstract
Streptomyces turgidiscabies Car8 is an actinobacterium that causes the economically important disease potato scab. Pathogenesis in this species is associated with a mobile pathogenicity island (PAISt) that site specifically inserts into the bacA gene in Streptomyces spp. Here we provide the 674,223 bp sequence of PAISt, which consists of two non-overlapping modules of 105,364 and 568,859 bp. These modules are delimited by three copies of an 8 bp palindromic sequence (TTCATGAA), that also is the integration site (att) of the element. Putative tyrosine recombinase (IntSt) and excisionase (XisSt) proteins are encoded just upstream of att-R. PAISt has regions of synteny to pathogenic, symbiotic and saprophytic actinomycetes. The 105,364 bp PAISt module is identical to a genomic island in Streptomyces scabies 87-22, while the 568,859 bp module contains only a short region of synteny to that genome. However, both modules contain previously characterized and candidate virulence genes.
MeSH terms
Base Sequence; Computational Biology; DNA Nucleotidyltransferases; Gene Order; Genes, Bacterial; Genomic Islands; Integrases; Molecular Sequence Annotation; Molecular Sequence Data; Recombination, Genetic; Solanum tuberosum; Streptomyces; Synteny; Tyrosine; Viral Proteins; Virulence
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