Selective localization of 4'-(9-acridinylamino)-methanesulfon-m-anisidide in B 16 melanoma.
Pharmacology, 1978;16(4):221-5.
Shoemaker DD, Legha SS, Cysyk RL
PMID: 204948
Impact factor: 3.429
Abstract
The acridine derivative 4'-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA, NSC-141549), a new antitumor agent undergoing phase I clinical evaluation, is highly active against B16 melanoma in vivo. AMSA was found to be concentrated in B16 melanoma cells in vivo and remained at high concentrations for at least 72 h. Subcellular fractionation of B16 melanoma cells revealed the drug to be bound to melanin granules. The results suggest the possible use of AMSA in human melanoma and the design of other antimelanoma agents that would exploit the affinity of the acridine nucleus for melanin.
MeSH terms
Acridines; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Male; Melanoma; Mesylates; Mice; Neoplasms, Experimental; Time Factors
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