[Immunogenicity and thymus-dependence of the polymerized alpha-toxoid of Clostridium perfringens].
Biull Eksp Biol Med, 1977/12;84(12):695-8.
Petrov RV, Shemanova GF, Kaverzneva ED, Kissel' VL, Panteleev EI
PMID: 202354
Abstract
Polymeric alpha-toxoid with a molecular weight of 450 000--600 000 was obtained by condensation of alpha-toxoid of Cl. perfringens, type A, with glutaric aldehyde. Experiments on guinea pigs showed that in the adsorbed preparations the immunogenic properties of both monomeric and polymeric alpha-toxoids are practically identical. The primary immune response after the immunization with nonadsorbed antigens was 3 times greater than that induced by the monomer. Polymerization of alpha-toxoid failed to change its thymus dependency.
MeSH terms
Animals; Clostridium perfringens; Gas Gangrene; Guinea Pigs; Hybridization, Genetic; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Polymers; Thymectomy; Thymus Gland; Toxoids
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