Hyperinsulinemic hypoglycemia: effect of epinephrine suppression.
Horm Metab Res, 1977/11;9(6):510-2.
Kansal PC, Boshell BR, Buse J, Bandisode MS, Roddam RF, Buse MG
PMID: 201552
Impact factor: 2.788
Abstract
The inhibitory effect of epinephrine on basal and tolbutamide-stimulated insulin release was studied in 5 patients with hyperinsulinemic hypoglycemia. Epinephrine inhibited both basal and tolbutamide-induced insulin release in patients with beta-cell adenoma and hyperplasia, but failed to inhibit insulin release in a patient with beta-cell carcinoma. The inhibition of basal insulin with epinephrine was maximum in patients with beta-cell hyperplasia. This differential inhibitory effect of epinephrine on insulin release may prove to be a useful screening test in the preoperative diagnosis of the nature of the lesion producing hyperinsulinemia.
MeSH terms
Adenoma; Adenoma, Islet Cell; Adult; Carcinoma; Epinephrine; Female; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Insulin; Insulin Secretion; Male; Middle Aged; Pancreatic Neoplasms; Tolbutamide
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