Synthesis and antitumor activities of phenanthrene-based alkaloids.
Molecules, 2009/12/07;14(12):5042-53.
Li S[1], Han L, Sun L, Zheng D, Liu J, Fu Y, Huang X, Wang Z
Affiliations
PMID: 20032876DOI: 10.3390/molecules14125042
Impact factor: 4.927
Abstract
A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 microM, respectively.
MeSH terms
Alkaloids; Antineoplastic Agents; Drug Screening Assays, Antitumor; Magnetic Resonance Spectroscopy; Phenanthrenes; Spectrometry, Mass, Electrospray Ionization
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