Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation.
Science, 2009/8/21;325(5943):1006-10.
Johnston RJ[1], Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S
Affiliations
PMID: 19608860DOI: 10.1126/science.1175870
Impact factor: 63.714
Abstract
Effective B cell-mediated immunity and antibody responses often require help from CD4+ T cells. It is thought that a distinct CD4+ effector T cell subset, called T follicular helper cells (T(FH)), provides this help; however, the molecular requirements for T(FH) differentiation are unknown. We found that expression of the transcription factor Bcl6 in CD4+ T cells is both necessary and sufficient for in vivo T(FH) differentiation and T cell help to B cells in mice. In contrast, the transcription factor Blimp-1, an antagonist of Bcl6, inhibits T(FH) differentiation and help, thereby preventing B cell germinal center and antibody responses. These findings demonstrate that T(FH) cells are required for proper B cell responses in vivo and that Bcl6 and Blimp-1 play central but opposing roles in T(FH) differentiation.
MeSH terms
Animals; Antibody Formation; Arenaviridae Infections; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Lineage; Cytokines; DNA-Binding Proteins; Gene Expression Regulation; Germinal Center; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Positive Regulatory Domain I-Binding Factor 1; Proto-Oncogene Proteins c-bcl-6; RNA, Messenger; Signal Transduction; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; Transcription Factors
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download