Effect of opiate receptor blockade on pain sensitivity in the rat.
Brain Res Bull, 1977/3-1977/4;2(2):157-9.
PMID: 195677
Impact factor: 3.715
Abstract
Blockade of opiate receptors by naloxone (2 mg/kg) was found to produce a significant increase in pain sensitivity as measured by the tail-flick test. This finding supports the view that endogenous opiate systems may play a role in the modulation of pain sensitivity. Naloxone, however, was found to have no effect on pain responsiveness as measured by tail-pinch. These findings, together with additional reports, suggest that endogenous opiate systems may exert differential actions on different sensory modalities.
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