C-type and intracisternal A-type virus particles during epidermal carcinogenesis by tobacco smoke condensate in BALB/c mice.
Br J Cancer, 1977/6;35(6):743-51.
PMID: 194615
Impact factor: 9.075
Abstract
Electron microscopic observations of sequential stages of skin carcinogenesis induced by tobacco smoke condensate (SC) and a cyclohexane fraction of tobacco smoke condensate (G) revealed an increase in incidence of intracisternal A particles within the epidermal cells. Tumours induced by SC also contained C-type particles, but these were not seen in G-induced tumours or after irritant or solvent treatment. There was no evidence of an increase in intracisternal A particles after irritant or solvent treatment. A direct relationship between the proliferation of A particles and neoplastic growth of BALB/c mouse epidermis appears likely. The data suggest possible activation of a latent C-type virus by SC.
MeSH terms
Animals; Endoplasmic Reticulum; Inclusion Bodies, Viral; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Neoplasms, Experimental; Oncogenic Viruses; Retroviridae; Skin Neoplasms; Smoking
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