Iron-promoted cyclization/halogenation of alkynyl diethyl acetals.
Org Lett, 2009/5/21;11(10):2113-6.
Affiliations
PMID: 19419210DOI: 10.1021/ol9005689
Impact factor: 6.072
Abstract
FeCl(3)- and FeBr(3)-promoted cyclization/halogenation of alkynyl diethyl acetals has been efficiently realized, selectively affording (E)-2-(1-halobenzylidene or alkylidene)-substituted five-membered carbo- and heterocycles which were then efficiently transformed to vinylarenes by Suzuki coupling. The present protocol has provided a new alternative route to vinylic C-Cl and C-Br bond formation.
More resources
EndNote: Download