Synthesis of isoxazolo[5,4-b]pyridines by microwave-assisted multi-component reactions in water.
J Comb Chem, 2009/5-2009/6;11(3):428-32.
Tu SJ[1], Zhang XH, Han ZG, Cao XD, Wu SS, Yan S, Hao WJ, Zhang G, Ma N
Affiliations
PMID: 19364093DOI: 10.1021/cc800212v
Abstract
A series of new polycyclic-fused isoxazolo[5,4-b]pyridines were obtained by a one-pot tandem reaction under microwave irradiation in water. Without any use of additional reagent or catalyst, the synthetic protocol represents a green one and makes this methodology suitable for library synthesis in drug discovery efforts.
MeSH terms
Combinatorial Chemistry Techniques; Isoxazoles; Microwaves; Molecular Structure; Pyridines; Small Molecule Libraries; Time Factors; Water
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