Alpha-receptor subsensitivity of isolated atria from rats following physical training or repeated ACTH-injections.
Acta Physiol Scand, 1977/4;99(4):457-61.
Siltovuori A, Tirri R, Harri MN
PMID: 193357
Abstract
Decreased chronotropic and inotropic sensitivity of isolated atria to phenylephrine but not to isoprenaline was found in rats following repeated physical training by swimming or repeated ACTH-injections. These changes were induced within a week of subjection of animals to these treatments. It is concluded, that these effects are mediated by increased adrenergic activity which results in this subsensitivity of alpha-receptors.
MeSH terms
Adrenocorticotropic Hormone; Animals; Dose-Response Relationship, Drug; Heart Atria; Isoproterenol; Male; Phenylephrine; Physical Exertion; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha
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