Effect of immunization on acute and latent infections of vaginouterine tissue with herpes simplex virus types 1 and 2.
J Infect Dis, 1977/5;135(5):744-52.
Walz MA, Price RW, Hayashi K, Katz BJ, Notkins AL
PMID: 192810
Impact factor: 7.759
Abstract
Inoculation of mice with herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) by the vaginal route resulted in viral shedding during the acute phase of the infection and the development of a latent infection in vaginouterine tissue lasting up to one year in greater than 25% of the animals. Immunization with either serotype of HSV markedly reduced viral shedding when animals were subsequently challenged with the homologous serotype, but immunization with HSV-2 was significantly less effective in preventing the development of a latent infection in the vaginouterine tissue after challenge than was immunization with HSV-1.
MeSH terms
Animals; Antibodies, Bacterial; Cytopathogenic Effect, Viral; Female; Ganglia, Autonomic; Ganglia, Spinal; Herpes Simplex; Immunization; Mice; Mice, Inbred A; Mice, Inbred BALB C; Simplexvirus; Uterine Diseases; Vaginal Diseases; Viral Vaccines
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