Adjuvant effect of amorphous silica on the immune response to various antigens in guinea pigs.
Int Arch Allergy Appl Immunol, 1977;53(2):97-103.
PMID: 191405
Abstract
The adjuvant effect of a subcutaneously injected amorphous silica (Aerosil) to various antigens was studied in guinea pigs. It was demonstrated that silica is able to enhance the humoral immune response to particulate and soluble antigens widely differing in molecular weight and that, in the system employed, adsorption of antigen on silica particles is not absolutely required for its adjuvanticity.
MeSH terms
Adjuvants, Immunologic; Adsorption; Animals; Antibody Formation; Antigens; Female; Freund's Adjuvant; Guinea Pigs; Hemagglutination Tests; Male; Passive Cutaneous Anaphylaxis; Silicon Dioxide; Solubility
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