Effect of methylazoxymethanol acetate on adenylate cyclase and 5'-nucleotidase in rat liver plasma membranes.
Cancer Lett, 1975/11;1(2):109-12.
PMID: 189900
Impact factor: 9.756
Abstract
A single tumorigenic dose of methylazoxymethanol acetate increased adenylate cyclase activity in total liver homogenates 70-100% by the seventh day after treatment. The increased activity occurred in the plasma membranes rather than in the nuclei and was accompanied by a significant increase in 5'-nucleotidase activity. The data indicate that the carcinogen may alter the structure of the plasma membrane.
MeSH terms
3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Azo Compounds; Cell Membrane; Female; In Vitro Techniques; Liver; Methylazoxymethanol Acetate; Neoplasms; Nucleotidases; Rats; Time Factors
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