Protriptyline: an effective agent in the treatment of the narcolepsy-cataplexy syndrome and hypersomnia.
Am J Psychiatry, 1977/2;134(2):183-5.
Schmidt HS, Clark RW, Hyman PR
PMID: 189623
Impact factor: 19.242
Abstract
The authors present five case reports illustrating that 10-20 mg of protriptyline in a single dose at bedtime can effectively control arousal dysfunction (sleep drunkenness and hypersomnia) and the narcolepsycataplexy syndrome without the apparent development of tolerance and without the side effects that are frequent complications of treatment with other agents. Although protriptyline was efficacious in controlling symptoms, it was found to have relatively poor REM sleep-suppressing properties.
MeSH terms
Adult; Cataplexy; Dibenzocycloheptenes; Disorders of Excessive Somnolence; Dreams; Drug Therapy, Combination; Hallucinations; Humans; Male; Narcolepsy; Pemoline; Protriptyline; Sleep Stages; Sleep Wake Disorders; Sleep, REM
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