Carcinogenicity test of two unstaurated derivatives of N-nitrosopiperdine in Sprague-Dawley rats.
J Natl Cancer Inst, 1976/12;57(6):1315-7.
PMID: 187801
Impact factor: 11.816
Abstract
Two unsaturated derivatives of N-nitrosopiperidine (NP), N-nitroso-1,2,3,6-tetrahydropyridine (NTP) and N-nitrosoguvacoline (NGC), were administered to Sprague-Dawley rats as solutions in drinking water at concentrations equimolar (0.88X10(-3) M) with those used to test NP. NTP gave rise to hepatocellular tumors in contrast to the esophageal or olfactory tumors that were induced by NP. NGS did not induce tumors under these test conditions.
MeSH terms
Animals; Areca; Carcinogens; Carcinoma, Hepatocellular; Esophageal Neoplasms; Female; Hemangioendothelioma; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Piperidines; Plants, Medicinal; Rats
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