Protection of monkeys against Machupo virus by the passive administration of Bolivian haemorrhagic fever immunoglobulin (human origin).
Bull World Health Organ, 1975;52(4-6):723-7.
Eddy GA, Wagner FS, Scott SK, Mahlandt BJ
PMID: 182406
Impact factor: 13.831
Abstract
Bolivian haemorrhagic fever immunoglobulin of human origin, given either prior to or shortly after experimental infection with Machupo virus, protected rhesus and cynomolgus monkeys against initial clinical illness. Some survivors developed severe neurological signs 30-47 days after virus inoculation and died 4-6 days later. Results from one of the experiments suggested that the development of neurological signs was associated more frequently with high doses of immunoglobulin than with intermediate or low doses.
MeSH terms
Animals; Antibodies, Viral; Arenaviruses, New World; Haplorhini; Hemorrhagic Fever, American; Hemorrhagic Fevers, Viral; Immunity, Active; Immunization; Immunoglobulins; Macaca fascicularis; Macaca mulatta
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