The insulin receptor of the turkey erythrocyte. Characterization of the membrane-bound receptor.
Biochim Biophys Acta, 1976/8/16;443(2):227-42.
PMID: 182262
Abstract
The insulin receptor of the turkey erythrocyte has previously been shown to be very similar to that of the mammalian insulin receptors. As a first step in the isolation of this receptor a highly purified plasma membrane fraction has been prepared. The binding characteristics of the purified membrane-bound receptor were identical to those found with intact erythrocytes, but the membrane preparation had very little insulin-degrading activity. Isolation of the membrane by the methods described gave a 100-fold purification of the insulin receptor with 67% yield.
MeSH terms
Animals; Cations, Divalent; Cell Membrane; Dose-Response Relationship, Drug; Erythrocytes; Insulin; Protein Binding; Receptors, Cell Surface; Sodium; Temperature; Turkeys
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