Regulation of neuronal properties by afferent connections. I. Functional changes in snail neurons following section of presysnaptic nerve fibers.
Brain Res, 1976/8/06;112(1):91-102.
PMID: 181117
Impact factor: 3.61
Abstract
The left cerebral connective of snail ganglia containing afferent inputs to a particular neuron was sectioned. One week after the operation synaptic potentials were not obtained when the connective was stimulated, and they had not reappeared after 60 days. The current-voltage relationship of denervated cells showed a rectification in the hyperpolarizing direction, whereas that of control cells had an ohmic behavior. Depolarization or conductance changes produced by ACh or carbachol showed a supersensitivity in denervated cells, evidenced by a shift to the left of the dose-response curve and an increase of the maximal responses obtained. The reversal potential of ACh shifted from--22 mV in the control to--8 mV in denervated cells. Depolarization produced by serotonin was similar in control and denervated cells.
MeSH terms
Acetylcholine; Animals; Carbachol; Dose-Response Relationship, Drug; Evoked Potentials; Membrane Potentials; Neural Conduction; Neural Pathways; Neurons; Neurons, Afferent; Serotonin; Snails; Synapses; Synaptic Transmission
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