Somatostatin and thyrotropin releasing hormone: central effect on sleep and motor system.
Pharmacol Biochem Behav, 1976/4;4(4):455-9.
Havlicek V, Rezek M, Friesen H
PMID: 180547
Impact factor: 3.697
Abstract
The hypothalamic hormones, somatostatin (SRIF or GH-RIH) and thyrotropin releasing hormone (TRH) applied intraventricularly into rat brain had a considerable effect on motor function and resulted in profound alterations in the sleep-waking pattern. While TRH induced primarily an increase in exploratory and motor stereotyped behavior, the effect of somatostatin was striking and prolonged: stereotyped circular running in many instances evolved into catatonia, paraplegia-in extension and/or tonic-clonic seizures.
MeSH terms
Animals; Male; Motor Activity; Pituitary Gland; Rats; Sleep; Sleep Stages; Sleep, REM; Somatostatin; Thyrotropin-Releasing Hormone; Time Factors
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