Proviral sequences of baboon endogenous type C RNA virus in DNA of human leukaemic tissues.
Nature, 1976/7/15;262(5565):190-5.
Wong-Staal F, Gillespie D, Gallo RC
PMID: 180434
Impact factor: 69.504
Abstract
Hybridisation of RNA from a baboon endogenous type C RNA virus to DNA from tissues of leukaemic patients indicates that a virus of this type is horizontally transmitted among humans. DNA from several patients with leukaemia hybridised 70% of the hybridisable RNA from baboon endogenous type C RNA virus (BaEV) and yielded hybrids of high tm, whereas DNA from normal human tissues hybridised only 23% of the BaEV RNA, and the tm of these hybrids was lower.
MeSH terms
Adult; Animals; Base Sequence; DNA, Neoplasm; DNA, Viral; Female; Humans; Leukemia, Myeloid; Leukocytes; Male; Middle Aged; Nucleic Acid Hybridization; Papio; Retroviridae; Spleen
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