Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants.

J Pediatr, 1976/6;88(6):931-6.

Wright PF, Shinozaki T, Fleet W, Sell SH, Thompson J, Karzon DT

PMID: 178852

Impact factor: 6.314

Abstract
Respiratory syncytial virus ts-1 is a live attenuated experimental vaccine which was administered intranasally to 25 infants 11 to 19 months of age. Clinical evaluation was carried out following a controlled, double-blind protocol which eliminated observer bias, assessed intercurrent illness, and was designed to detect virus transmission. At the low dose of virus of virus used (100 TCID50) 8 of the 25 recipients were successfully infected with RS virus ts-1 as determined by virus shedding or antibody response.
MeSH terms
More resources
EndNote: Download