Transfer RNA methylase activity and capacity during aflatoxin B1-induced hepatocellular carcinogenesis.
Cancer Res, 1976/6;36(6):2013-8.
Busby WF Jr, Paglialunga S, Newberne PM, Wogan GN
PMID: 178440
Impact factor: 13.312
Abstract
Transfer RNA methylase (tRNA methylase) activity and capacity were monitored in whole-rat-liver preparations during the induction of hepatocellular carcinomas by an 8-week aflatoxin B1 dosing regimen that produced minimal toxic effects. Significant phases of elevated tRNA methylase capacity occurred at 6 to 9 weeks (20%) and 24 to 29 weeks (40%). No significant change in tRNA methylase activity was noted over the course of the 55-week experiment. Higher aflatoxin B1 doses, producing acute toxic liver damage, resulted in elevated tRNA methylase activity (50%) and capacity (30%) at least as early as 1 week after dosing. Experiments with individual nodular lesions excised from livers of rats continuously fed a diet containing 2 ppm aflatoxin B1 demonstrated similarly elevated tRNA methylase activities and capacities in hyperplastic (preneoplastic)nodules, with and without histological evidence of carcinoma.
MeSH terms
Aflatoxins; Animals; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Precancerous Conditions; Rats; tRNA Methyltransferases
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