Cyclic AMP content of gingival fluid in women taking oral contraceptives.
J Oral Pathol, 1975/12;4(6):291-6.
Grower MF, Lyon DR, Levin MP, Chandler DW
PMID: 177743
Abstract
Gingival fluid samples were collected from 12 healthy adult women who ranged in age from 19 to 34 years. Seven subjects with normal menstrual cycles who received no medications acted as controls while five subjects who had been using oral contraceptives for a minimum of 17 months constituted the experimental group. The women using birth control pills showed a 53% increase in the gingival fluid volume versus the controls. Radioimmunoassay revealed a mean concentration of cyclic adenosine monophosphate (cAMP) in the gingival fluid of 3.8-10(-6)M in the controls and 1.9-10(-6)M in subjects using oral contraceptives, although the total amount of cAMP present in the fluid from both groups was equal. These gingival fluid cAMP levels were a hundredfold higher than those measured in serum and saliva.
Keywords: Adenosine Cyclic Monophosphate--analysis; Biology; Clinical Research; Comparative Studies; Contraception; Contraceptive Methods; Family Planning; Oral Contraceptives; Physiology; Research Methodology; Studies
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