Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma.
J Proteome Res, 2007/9;6(9):3705-17.
Staab CA[1], Ceder R, Jägerbrink T, Nilsson JA, Roberg K, Jörnvall H, Höög JO, Grafström RC
Affiliations
PMID: 17696463
Impact factor: 5.37
Abstract
Normal and two transformed buccal keratinocyte lines were cultured under a standardized condition to explore mechanisms of carcinogenesis and tumor marker expression at transcript and protein levels. An approach combining three bioinformatic programs allowed coupling of abundant proteins and large-scale transcript data to low-abundance transcriptional regulators. The analysis identified previously proposed and suggested novel protein biomarkers, gene ontology categories, molecular networks, and functionally impaired key regulator genes for buccal/oral carcinoma.
MeSH terms
Biomarkers, Tumor; Cell Line, Transformed; Cheek; Computational Biology; Culture Media, Serum-Free; Humans; Keratinocytes; Models, Molecular; Mouth Neoplasms; Proteins; Proteomics; RNA, Messenger; Transcription Factors; Transcription, Genetic
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