Corneal transplantation reaction in avascular keratoconus patients due to HLA-associated immune aberration against infection. A hypothesis.
Invest Ophthalmol Vis Sci, 1977/7;16(7):644-6.
Vannas S, Vannas A, Tilikainen A
PMID: 17576
Impact factor: 4.925
Abstract
HLA-B12 and HLA-B27 appeared to be characteristic of avascular keratoconus patients at risk of developing a corneal allograft reaction, which was mainly of late type and triggered by a nasopharyngeal infection. Equally incompatible grafts to patients with HLA-B5 had an uneventful course. This may be inference to the role of HLA-associated immune resistance factors, which necessitate the search for histocompatible corneal grafts also for avascular recipients bearing such indicators of risk.
MeSH terms
Cornea; Corneal Transplantation; Graft vs Host Reaction; HLA Antigens; Histocompatibility Antigens; Humans; Keratoconus; Phenotype; Postoperative Complications; Risk; Transplantation, Homologous
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