[Experimental investigations on the accumulation of radioactive compounds in autochtonal tumors in the rat (author's transl)].
Arch Geschwulstforsch, 1975;45(4):313-23.
PMID: 173256
Abstract
For the first time results of investigations on rats with radioactive compounds in autochtonal tumors of the central nervous system, induced via placenta by Ethyl-Nitrose-Urea (ENU), are reported. In contrast to transplantation tumors the tumors induced by ENU are comparable in regard to the szintigrafic results with human brain tumors. The radiopharmaceuticals 131I-HSA, 99mTc-Pertechnetate, 203Hg-Chlormerodrin and 113m/111In-DTPA are similar to human brain tumors taken up by the ENU-tumors. For these findings it may be important, that the ENU-tumors are of neurogenic origin and do not differ histologically from the human brain tumors. The accumulation of the radioactive substances in ENU-tumors can be explained with the lesion at the blood-brain-barrier and at the blood-nerv-barrier. Therefore, it is discussed that the mechanism of the uptake is similar in human brain neoplasms and in ENU-tumors of the brain. The ENU-tumor model is suitable for testing new radiopharmaceuticals before their application in men.
MeSH terms
Animals; Blood-Brain Barrier; Brain Neoplasms; Chlormerodrin; Ethylnitrosourea; Female; Humans; Indium; Male; Neoplasms, Experimental; Neoplasms, Nerve Tissue; Pentetic Acid; Radioisotopes; Rats; Serum Albumin
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