Tumorigenicity of mouse-human diploid hybrids in nude mice.
Science, 1975/12/19;190(4220):1200-2.
PMID: 173020
Impact factor: 63.714
Abstract
Somatic cell hybrids between normal mouse cells and simian virus 40 (SV40)-transformed human cells, which contained a diploid complement of mouse chromosomes and the human chromosome 7 carrying the genome of SV40, were tumorigenic in nude mice. One single copy of human chromosome 7 per hybrid cell appeared to be sufficient for the tumorigenicity of the hybrids.
MeSH terms
Animals; Antigens, Neoplasm; Antigens, Viral; Cell Transformation, Neoplastic; Chromosomes, Human, 6-12 and X; Humans; Hybrid Cells; Karyotyping; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Simian virus 40
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