Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides.
Bioorg Med Chem, 2007/3/01;15(5):1947-58.
Zanatta N[1], Alves SH, Coelho HS, Borchhardt DM, Machado P, Flores KM, da Silva FM, Spader TB, Santurio JM, Bonacorso HG, Martins MA
Affiliations
PMID: 17240153
Impact factor: 3.461
Abstract
The synthesis and characterization of a new series of furan-3-carboxamides, from the aromatization of 4-trichloroacetyl-2,3-dihydrofuran to 3-trichloroacetyl furan followed by nucleophilic displacement of the trichloromethyl group or the corresponding carboxylic acid chloride by nitrogen-containing compounds, is presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including yeast, filamentous fungi, bacteria, and alga. Some of the furan-3-carboxamides exhibited significant in vitro antimicrobial activity. QSAR investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.
MeSH terms
Amides; Antifungal Agents; Fungi; Furans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Quantitative Structure-Activity Relationship; Spectrometry, Mass, Electrospray Ionization
More resources
EndNote: Download