Arsine toxicity aboard the Asiafreighter.
Br Med J, 1975/9/06;3(5983):559-63.
Wilkinson SP, McHugh P, Horsley S, Tubbs H, Lewis M, Thould A, Winterton M, Parsons V, Williams R
PMID: 169942
Abstract
Eight sailors on board the Asiafreighter were exposed to arsine that had escaped from a cylinder in the cargo hold. Four suffered severe toxicity and within a few hours had developed fever, weakness, nausea, vomiting, diarrhoea, abdominal pain, and haemoglobinuria. These patients had pronounced intravascular haemolysis, which in one patient was complete. This patient was also stuporose and anoxic, a condition attributed to failure of oxygen transport and sludging of red cell debris in the cerebral and pulmonary circulations, but he regained a normal level of consciousness after exchange transfusion. Evidence of marrow depression was present: the reticulocyte response to the haemolysis was poor and there was a thrombocytopenia. All four patients developed renal failure, one being totally anuric for five weeks. Two patients developed peripheral neuropathy, and one was still severely disabled six months after the incident. The other four patients had a similar, though less severe, illness.
MeSH terms
Acute Kidney Injury; Adult; Arsenic Poisoning; Arsenicals; Bone Marrow Examination; Chemical and Drug Induced Liver Injury; Creatinine; Dexamethasone; Diarrhea; Environmental Exposure; Exchange Transfusion, Whole Blood; Fever; Gas Poisoning; Hair; Hemoglobinuria; Hemolysis; Humans; Liver; Male; Middle Aged; Nausea; Naval Medicine; Paresthesia; Peripheral Nervous System Diseases; Thrombocytopenia; Time Factors; Urea; Vomiting
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