pyrR identical to pyrH in Salmonella typhimurium: control of expression of the pyr genes.
J Bacteriol, 1975/9;123(3):851-4.
PMID: 169229
Impact factor: 3.476
Abstract
Mutants of Salmonella typhimurium showing constitutive synthesis of the pyrimidine biosynthetic enzymes coded for by the pyrA-F genes (G. A. O'Donavan and J. C. Gerhart, 1972) have been reinvestigated. The high rate of expression of the pyrB-F genes in these mutants as well as their pyrimidine excretion is shown to be due to mutations in the gene pyrH encoding uridine 5'-monophosphate kinase. Thus, the term pyrR used for these mutants should be replaced by the designation pyrH.
MeSH terms
Aspartate Carbamoyltransferase; Enzyme Repression; Genes; Genes, Regulator; Mutation; Phosphotransferases; Pyrimidines; Salmonella typhimurium; Uridine; Uridine Kinase
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