Fetal calf serum alters cyclic adenosine 3',5'-monophosphate's effect on heme synthesis in vitro.
Experientia, 1975/8/15;31(8):981-3.
PMID: 169145
Abstract
An investigation of the effect of cAMP on heme synthesis of rat bone marrow cells revealed that at 10(-2) M this cyclic nucleotide inhibits heme synthesis and that optimum stimulation occurs at 10(-4) M. Some unidentified constituent of fetal calf serum in the culture medium modifies the direction and degree of cAMP's effect.
MeSH terms
Animals; Blood; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Heme; Male; Rats
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