Hepatic clearance of adenosine 3:5-cyclic monophosphate from plasma in the rat.
Biochem J, 1975/2;146(2):509-12.
PMID: 168878
Impact factor: 3.766
Abstract
Rats were given intravenous injections of cyclic [3H]AMP and the disappearance of radioactivity from plasma and its appearance in bile were followed. Livers were removed and the cyclic [3H]AMP content was measured. The binding of radioactivity to soluble proteins was measured after preparations of a cytoplasmic fraction. Experiments in vitro to determine the ability of hepatic cytoplasmic proteins to bind cyclic [3H]AMP were also carried out. A role for cytoplasmic proteins in the clearance of cyclic AMP from plasma is discounted.
MeSH terms
Animals; Cyclic AMP; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Protein Binding; Proteins; Rats; Time Factors
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