Correlation of survival from murine cytomegalovirus infection with spleen cell responsiveness to Concanavallin A.
Proc Soc Exp Biol Med, 1975/6;149(2):443-5.
PMID: 168587
Abstract
Spleen cells from nonlethally MCMV-infected weanling and adult DBA/2 mice had diminished responses to Con A stimulation. In contrast, only lethal MCMV infections were associated with a complete suppression of the Con A response. The immune response to SRBC was depressed even in asymptomatic infections of weanling and adult mice. A marked maturation of resistance to the lethal effects of MCMV infection was found to occur during the fourth week of life.
MeSH terms
Age Factors; Animals; Antigens; Concanavalin A; Cytomegalovirus; Erythrocytes; Female; Injections, Intraperitoneal; Mice; Mice, Inbred DBA; Sheep; Spleen; T-Lymphocytes; Viral Plaque Assay; Virus Diseases
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