Comparison of an H2 receptor antagonist and a neutralizing antacid on postprandial acid delivery into the duodenum in patients with duodenal ulcer.
Gastroenterology, 1977/7;73(1):11-4.
PMID: 16806
Impact factor: 33.883
Abstract
Measurement of the postprandial rate of acid delivery into the duodenum directly assessed the efficacy of two radically different acid-reducing therapies for duodenal ulcer disease. Cimetidine, 400 mg, with an ordinary solid meal decreased the 4-hr delivery of titratable acid and hydrogen ion into the duodenum by 63 and 86%, respectively (P less than 0.01 versus control). Liquid Maalox, 30 ml, 1 and 3 hr after an identical meal reduced 4-hr delivery of acid by 47 and 74%, respectively (P less than 0.01 versus control). During the study period, the H2 receptor antagonist effected a continuous reduction in gastric acidity and the delivery of acid into the duodenum. The liquid neutralizing antacid produced a more fluctuating decrease in these parameters. However, given in these dosages, the magnitude and duration of the acid-reducing effect were similar for both treatments.
MeSH terms
Aluminum Hydroxide; Drug Evaluation; Duodenal Ulcer; Duodenum; Gastric Acidity Determination; Gastric Juice; Gastrointestinal Motility; Histamine H2 Antagonists; Humans; Intubation, Gastrointestinal; Magnesium; Magnesium Hydroxide; Methods; Stomach; Time Factors
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