Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids.
Mol Microbiol, 2006/6;60(6):1329-43.
Dai Q[1], Restrepo BI, Porcella SF, Raffel SJ, Schwan TG, Barbour AG
Affiliations
PMID: 16796672
Impact factor: 3.979
Abstract
The relapsing fever agent Borrelia hermsii undergoes multiphasic antigenic variation through gene conversion of a unique expression site on a linear plasmid by an archived variable antigen gene. To further characterize this mechanism we assessed the repertoire and organization of archived variable antigen genes by sequencing approximately 85% of plasmids bearing these genes. Most archived genes shared with the expressed gene a
MeSH terms
Antigenic Variation; Base Sequence; Borrelia; Crossing Over, Genetic; DNA, Bacterial; DNA, Circular; Molecular Sequence Data; Plasmids; Recombination, Genetic; Repetitive Sequences, Nucleic Acid
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download