Immune deficiency in congenital rubella and other viral infections.
Birth Defects Orig Artic Ser, 1975;11(1):234-8.
South MA, Montgomery JR, Rawls WE
PMID: 167881
Abstract
No immunologic explanation has been found for the chronicity commonly observed in congenital viral infections. In the presence of a humoral immune response, there is continued viral excretion--in rubella for many months, and in the herpes viruses perhaps for life. Infection with rubella early in utero has a profound effect on the developing immune system. Defects observed are: complete immune paralysis, PHA unresponsiveness, immunoglobulin abnormalities, and loss of antibody to rubella. These defects are transient; absence of IgA may be permanent. No such defects have been observed in other congenital viral infections, but precocious development of immune globulin levels and germinal follicles occurs.
MeSH terms
Antibodies, Viral; Antibody Formation; B-Lymphocytes; Cell Division; Cells, Cultured; Child, Preschool; Chronic Disease; Cytomegalovirus; Cytomegalovirus Infections; Female; Fetal Blood; Growth Disorders; Herpesviridae Infections; Humans; Immune Tolerance; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Immunosuppression Therapy; Infant; Infant, Newborn; Lectins; Lymphocyte Activation; Pregnancy; Rubella; Simplexvirus
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