Pathogenesis of pyelonephritis. Escherichia coli-induced renal ultrastructural changes.
Invest Urol, 1975/7;13(1):47-51.
PMID: 166961
Abstract
Escherichia coli-induced renal ultrastructural changes were observed 4 hr after the intravenous injection of 2 times 10-minus 6 bacteria. The initial changes consisted of mitochondrial swelling followed by intracellular vacuolation, nuclear membrane dilation, and increased lysosomal phagocytic activity. Alterations in the appearance of proximal tubular lysosomes included a loss of osmiophilic staining properties. Many of the involved cells showed necrosis and can presumably act as a nidus for bacterial proliferation.
MeSH terms
Animals; Cell Nucleus; Escherichia coli; Female; Inclusion Bodies; Kidney; Kidney Tubular Necrosis, Acute; Kidney Tubules, Distal; Kidney Tubules, Proximal; Lysosomes; Mitochondrial Swelling; Pyelonephritis; Rats
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