Proflavine photodynamic viral inactivation in herpes simplex keratitis.
Am J Ophthalmol, 1975/6;79(6):941-8.
O'Day DM, Jones BR, Poirier R, Pilley S, Chisholm I, Steele A, Rice NS
PMID: 166561
Impact factor: 5.488
Abstract
We used the photodynamic inactivation technique with proflavine as the photoactive dye to treat herpetic epithelial keratitis in a preliminary study of patients who had idoxuridine toxicity or resistance. A comparative study with idoxuridine in treating dendritic ulcerations of the cornea showed a good therapeutic effect. But the investigation was suspended when adverse reactions, consisting of a generalized epithelial keratitis and an anterior uveitis, possibly of phototoxic origin, developed in a few patients receiving treatment. The ulcers treated by photodynamic inactivation apparently healed by a process of "debridement" followed by subsequent re-epithelialization.
MeSH terms
Acridines; Adult; Anterior Chamber; Betamethasone; Edema; Female; Humans; Idoxuridine; Keratitis, Dendritic; Male; Middle Aged; Phototherapy; Prednisolone; Prednisone; Proflavine; Recurrence; Simplexvirus; Suppuration; Wound Healing
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