Cellular cooperation in transformation by EB virus.
Res Commun Chem Pathol Pharmacol, 1975/3;10(3):554-8.
PMID: 166423
Abstract
Human lymphoid cells transformed by Epstein-Barr (EB) virus are thought to be B-lymphocytes. Transformation of human mononuclear leukocytes by Epstein-Barr virus was decreased or lost by removing adhering or nonadhering mononuclear cells from the mixtures of peripheral blood leukocytes but was not decreased by removing T-lymphocytes. Recombining adherent and nonadherent mononuclear cells without T-lymphocytes restored transformability, but conditioned medium from cultures of adherent cells did not. Cooperation between non-adherent (B-cells) and adherent cells (monocytes) is necessary for EB virus transformation.
MeSH terms
Adult; Animals; Blood; Cytopathogenic Effect, Viral; Female; Herpesvirus 4, Human; Humans; In Vitro Techniques; Infant, Newborn; Leukocytes; T-Lymphocytes; Umbilical Cord
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