[Participation of cerebral dopamine receptors in activating the endocrine function of the male sex glands].
Probl Endokrinol (Mosk), 1975/1-1975/2;21(1):67-70.
Naumenko EV, Serova LI, Maslova LN
PMID: 166372
Abstract
One hour after the administration of 10 gamma of dopamine into the third ventricle of the brain to male albino rate the level of testosterone in the peripheral blood plasma (determined fluorimetrically) proved to double. Such effect was absent against the background of complete postero-lateral or posterior deafferentation of the meidal-basal area of the hypothalamus (MBAH). Section of the anterior nervous connections of the MBAH with the preoptic region failed to prevent the stimulating action of dopamine administered into the ventricle: blood testosterone level doubled as in the rats with an intact hypothalamus. A conclusion was made that dopamine receptors associated with the endocrine function of the male gonad were located outside the MBAH. Nervous tracts conducting this excitation reached the hypophyseotrophic zone of the hypothalamus through its posterior connections.
MeSH terms
Animals; Brain Mapping; Dopamine; Hypothalamus; Male; Neural Pathways; Neurons, Afferent; Rats; Receptors, Cell Surface; Stimulation, Chemical; Testis; Testosterone
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