Timed-release depot for anticancer agents.
J Pharm Sci, 1975/1;64(1):115-6.
PMID: 166155
Impact factor: 3.784
Abstract
The timed-release of anticancer agents from composities with poly (lactic acid) was studied in rats. In the case of cyclophosphamide-poly (lactic acid) composites, 67% of the administered dose was released within 34 days. With cis-dichlorodiammineplatinum (II), the amount of drug released was only 9.3% within the same period. This difference might be attributed to the different solubilities of these two drugs in the polymer. Electron spectroscopy chemical analysis, a new tool, was used to investigate the extent of diffusion of drugs in polymer films.
MeSH terms
Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Delayed-Action Preparations; Electron Spin Resonance Spectroscopy; Lactates; Male; Nitrogen; Phosphorus; Platinum; Polymers; Rats; Time Factors
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