An experimental inactivated vaccine against bluetongue.
Vet Rec, 1975/3/29;96(13):284-7.
Parker J, Herniman KA, Gibbs EP, Sellers RF
PMID: 165609
Impact factor: 2.56
Abstract
Bluetongue virus grown in BHK cells was shown to be inactivated in concentrations of betapropiolactone (BPL) higher than 0-15 per cent. When the virus, inactivated with 0-2 per cent BPL and prepared as a double emulsion vaccine, was injected into Cypriot sheep, no untoward reactions were observed and neutralising antibodies developed. The antibody titre reached a high level and persisted for at least a year. After re-vaccination, a secondary response was observed. A bivalent vaccine elicited a response to both virus types incorporated. The possibilities of using a polyvalent inactivated vaccine are discussed.
MeSH terms
Animals; Antibody Formation; Antigens, Viral; Bluetongue; Bluetongue virus; Cells, Cultured; Cytopathogenic Effect, Viral; Injections, Intramuscular; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney; Lactones; Neutralization Tests; Propionates; Reoviridae; Sheep; Viral Vaccines
More resources
EndNote: Download