Estrogen-directed synthesis of specific prostaglandins in uterus.
Proc Natl Acad Sci U S A, 1975/4;72(4):1420-4.
Ham EA, Cirillo VJ, Zanetti ME, Kuehl FA Jr
PMID: 165507
Impact factor: 12.779
Abstract
Endogenous uterine prostaglandin levels were monitored in the cycling rat and prostaglandins of the F-type were found to rise at proestrus when estrogen levels have been shown to be maximal. Evidence that this is an estrogen-induced event is furnished by the finding that estradiol-17beta caused a similar rise in prostaglandin F levels in uteri of ovariectomized rats, an action blocked by coadministration of progesterone. Examination of in vitro prostaglandin synthetase by uterine microsomal fractions from cycling rats and estrogen-treated ovariectomized rats revealed that the action of estrogen to control prostaglandin synthesis in a directional manner is accomplished, at least in part, by regulation of the prostaglandin synthetase complex, resulting in a patterned alteration in the ratio of prostaglandin F to prostaglandin E. These results demonstrate that prostaglandins are involved in the expression of estrogen action in the rat uterus.
MeSH terms
Animals; Castration; Cyclic AMP; Cyclic GMP; Diestrus; Estradiol; Estrogens; Estrus; Female; Indomethacin; Microsomes; Ovary; Pregnancy; Proestrus; Progesterone; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins F; Rats; Time Factors; Uterus
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