A specific, high-affinity, limited-capacity estrogen binding component in the cytosol of human fetal pituitary and brain tissues.
J Clin Endocrinol Metab, 1975/5;40(5):909-12.
Davies J, Naftolin F, Ryan KJ, Siu J
PMID: 165222
Impact factor: 6.134
Abstract
A macromoleclar component which binds 3H-estradiol with high affinity and limited capacity is present in the 150,000 x g supernatant fraction of pituitary, hypothalamus, cortex, and limbic system of both male and female human fetwses. 17 beta-estradiol and 17alpha-ethinylestradiol effectively compete with 3H-estradiol for binding sites while testosterone, dihydrotes-tosterone, and cortisol do not. The binding component is different from sexhormone-binding-globulin. It is present in these tissues in relatively large amounts and it is tentatively identified as an estrogen recptor.
MeSH terms
Binding Sites; Binding, Competitive; Brain; Cerebral Cortex; Cytosol; Dihydrotestosterone; Estradiol; Ethinyl Estradiol; Female; Fetus; Humans; Hydrocortisone; Hypothalamus; Limbic System; Male; Nerve Tissue Proteins; Organ Specificity; Pituitary Gland; Pregnancy; Protein Binding; Proteins; Receptors, Cell Surface; Testosterone
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