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164879
Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy.

Br J Ind Med, 1975/2;32(1):31-8.

Edwards PM

PMID: 164879

Abstract
N-Hydroxymethylacrylamide, N-methylacrylamide, and N,N-diethylacrylamide produce peripheral neuropathy in rats. Seven other compounds related to acrylamide do not produce neuropathy. Rats given one of the three neurotoxic compounds are more susceptible to acrylamide. A regime for testing acrylamide analogues for neuro-toxicity is suggested. DDT, phenobarbitone, or high dietary concentrations of vitamin A or E have no effect on the development of acrylamide neuropathy in rats. Acrylamide produces neuropathy in hens but not in frogs or goldfish.
MeSH terms
Acrylamides; Animals; Ataxia; Brachial Plexus; Chickens; DDT; Female; Goldfish; Male; Nerve Degeneration; Peripheral Nervous System Diseases; Peroneal Nerve; Phenobarbital; Rana temporaria; Rats; Sciatic Nerve; Species Specificity; Spinal Cord; Vitamin A; Vitamin E
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