Viral hepatitis, type A. Identification by specific complement fixation and immune adherence tests.
N Engl J Med, 1975/5/29;292(22):1141-3.
Krugman S, Friedman H, Lattimer C
PMID: 164627
Impact factor: 176.079
Abstract
Hepatitis A antibody was detected by specific immune adherence and complement-fixation tests in a study involving 473 serum specimens from 20 patients who had viral hepatitis, Type A. In all 20 patients who had no detectable immune adherence antibody (less than 1:5) before onset of hepatitis high levels (greater than or equal to 1:1024) developed one to four weeks later, occasionally reaching peak levels exceeding greater than or equal to 1:81,920 several months thereafter. Five to 10 years later the immune adherence antibody levels ranged between 1:640 and 1:20,480. In general, the complement-fixation test was not as sensitive or as specific as the immune adherence test. These findings indicate that the immune adherence test should be a valuable tool for diagnosis, for epidemiologic surveys, for identification of susceptible and immune persons, for quantitative assays of gamma globulin and for identification of hepatitis A virus in attempts to propagate the virus in cell culture.
MeSH terms
Animals; Antibodies, Viral; Antigens, Viral; Aspartate Aminotransferases; Complement Fixation Tests; Haplorhini; Hemagglutination Tests; Hepatitis A; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Antigens; Hepatitis B virus; Hepatovirus; Humans; Immune Adherence Reaction; Time Factors
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